Manchester City travel to Stade Vélodrome to take on Marseille in Group C of the UEFA Champions League. This is the first time the two sides have met in European competition.
Liverpool welcome Midtjylland to Anfield in Group D of the UEFA Champions League. Liverpool have lost just one of their last 26 home games in all European competitions.
Chelsea travel to Krasnodar Stadium to face Krasnodar in Group E of the UEFA Champions League. This will be Krasnodar's first ever home Champions League tie.
Juventus host Barcelona in Group G at Juventus Stadium. This will be the first Champions League meeting between Lionel Messi and Cristiano Ronaldo since 2011.
Manchester United host RB Leipzig at Old Trafford in Group H of the UEFA Champions League. United are unbeaten in their last 10 home games against German sides.
Lille host Celtic in Group H of the UEFA Europa League at Stade Pierre-Mauroy. Lille's Yusuf Yazici netted a hat-trick against Sparta Prague on matchday one.
Antwerp take on Tottenham at Bosuilstadion in Group J of the UEFA Europa League. Spurs have managed just one win from their last eight Europa League away games.
Leicester City travel to the Athens Olympic Stadium to take on AEK Athens in Group G of the UEFA Europa League. Leicester prevailed 3-0 winners over Zorya on matchday one.
Arsenal host Dundalk at the Emirates Stadium in Group B of the UEFA Europa League. This is the first time that Arsenal will face Irish opposition in UEFA competition.
Rangers host Lech Poznan at Ibrox Stadium in Group D of the UEFA Europa League. Rangers striker Kemar Roofe scored the longest-range goal in UEFA Europa history on matchday one.